Recent family studies suggest heritability estimates of CRP ranging from 27–40%,[11], [12] and it is hypothesized that genetic variation in the CRP gene may influence plasma CRP levels and subsequent risk of CHD. Several studies have reported individual single nucleotide polymorphisms (SNPs) to be associated with CRP levels,[13]–[21] and of these, Zee et al.,[15] which included SNP 2667G>C, Casas et al.,[19] which included SNP 3014G>A, also examined associations with cardiovascular events. Both studies reported no association with the individual SNPs and risk of cardiovascular disease.
