al., 2009) increased nose pokes in the THC-associated aperture in mice even in the absence of 2-AG co-administration (Long et al., 2009c). Cannabinoid CB1 receptor mediation of this effect is suggested by its rimonabant reversal, as well as by the pronounced increase in brain 2-AG concentration produced by JZL184 (Long et al., 2009c). While JZL184 did not fully substitute for THC in wildtype mice or in rats in the present study, full substitution was observed in FAAH(−/−) mice trained to discriminate THC from vehicle and in wildtype mice treated with the dual FAAH/MAGL inhibitor JZL 195 (Long et al., 2009c). Similarly, maximal responding on the THC-associated lever in rats in the present study (68%) was engendered by co-administration of the FAAH and MAGL inhibitors, URB597 (30 mg/kg) and JZL184 (16 mg/kg), respectively.
