2003) (Figure 2), bearing a striking resemblance to human subjective reports. These results demonstrate that the elevation in brain reward thresholds following prolonged access to cocaine failed to return to baseline levels between repeated, prolonged exposure to cocaine self-administration (i.e., residual hysteresis), thus creating a greater and greater elevation in “baseline” ICSS thresholds. These data provide compelling evidence for brain reward dysfunction in escalated cocaine self-administration that provide strong support for a hedonic allostasis model of drug addiction.
