Chunk #34 — Polygenic Risk Scores: A Bridge Between Population Variation and Individual Differences — PRS Practicalities — Technical Considerations. — Differences from other heritability metrics:
are significantly genetically correlated (SNP-rg > 0); however, we view them to be philosophically different (although, SNP-h2 has attractive technical characteristics)2. Twin-h2 and SNP-h2 represent the total variance accounted for by latent genetic and measured common genomic variation, respectively. On the other hand, the essence of PRS is “prediction” in an independent sample, using a metric that is algebraically simple (weighted average), so that it might be viewed to have future generalizable clinical relevance.
