These results support the utility of using genetic approaches to advance the understanding of complex trait comorbidities. Given the significant morbidity and mortality associated with the comorbid conditions, AD and MD, understanding mechanisms underlying these associations not only address important public health concerns but also has the potential to facilitate prevention and intervention efforts. As discovery GWAS increase in sample size, future research will have the power to examine patterns of genetic correlation and causal mechanisms by important stratifications such as across diverse ancestries and sex.
