after 4 weeks of treatment. Additionally, Zhao et al. compared peripheral blood DNA methylome patterns between 10 AUD subjects and 10 paired siblings (without AUDs).38 They identified 865 hypomethylated and 716 hypermethylated CpG sites in peripheral blood DNAs of AUD subjects, and the most hypomethylated CpG site was located in the promoter of SSTR4 (coding for somatostatin receptor 4) while the most hypermethylated CpG site was located in the promoter GABRP (coding for γ-aminobutyric acid A receptor, Pi).
