Exome sequencing and whole genome sequencing (ES/WGS) have become important tools for identifying alleles underlying both Mendelian and complex health-related traits [Bamshad et al., 2011; Bamshad et al., 2012; Biesecker, 2010; Gonzaga-Jauregui et al., 2012]. The number of individuals who have undergone ES/WGS over the past few years has steadily increased, and is likely to rapidly accelerate with the advent of commercial CLIA-approved sequencing services that have made ES/WGS widely available to researchers and clinicians.
