To further attempt to interpret the list of differentially expressed genes and isoforms, we also conducted a series of structured tests to evaluate their functional enrichment, including evaluating primary hypotheses previously implicated by genetic findings in schizophrenia research (e.g., targets of regulation by FMRP, fragile X mental retardation protein), and performing exploratory analyses of a large number of gene sets (such as those obtained from Gene Ontology). In brief, we found no convincing patterns to the primary or exploratory hypotheses, after correction for multiple set testing, confounders such as gene size, and after combining results over multiple enrichment tests.
