gene discovery analyses may improve phenotype prediction via polygenic scores when discovery samples are adequately large to model differences in genetic liabilities across development. Beyond applications to polygenic scoring, larger developmentally-informative discovery analyses may also facilitate the identification of age-matched genetic instruments for improved Mendelian randomization studies. Our results suggest that very large sample sizes will be required to reach this goal using the approach described in the current work. The results presented here are an initial step towards toward this goal and lay a foundation for future molecular genetic studies of developmental variability in the genetic underpinnings of alcohol use behaviors and the subsequent possibility of genetically-informed, age-matched phenotype prediction.
