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Chunk #0 — Introduction

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International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.
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Post-traumatic stress disorder (PTSD) is a commonly occurring mental health consequence of exposure to extreme, life threatening stress, and/or serious injury/harm. PTSD is frequently associated with the occurrence of comorbid mental disorders such as major depression1 and other adverse health sequelae including type 2 diabetes and cardiovascular disease2,3. Given this high prevalence and impact, PTSD is a serious public health problem. An understanding of the biological mechanisms of risk for PTSD is therefore an important goal of research ultimately aimed at its prevention and mitigation4,5.