Family history of AUD, which captures both genetic and environmental sources of risk, is a strong and consistent predictor of risk for AUD (Dawson et al., 1992, Karriker-Jaffe et al., 2021, Lai et al., 2022a). Many studies have investigated the relationship between family history of AUD and remission but without significant results (Dawson, 1996, Dawson et al., 2005, Bottlender and Soyka, 2005, Knop et al., 2007, Penick et al., 2010, Gilder et al., 2008, Dawson et al., 2007, Lopez-Quintero et al., 2011). However, we have reported that family history of remission, explicitly defined as not having active AUD at time of interview, was associated with remission in young adult twins (McCutcheon et al., 2012) and in the Collaborative Study on the Genetics of Alcoholism (COGA) sample (McCutcheon et al., 2017). COGA participants with lifetime AUD were more than three times as likely to be abstinent remitted if they had a first-degree relative who was abstinent five years after AUD treatment when compared to participants whose relative had active AUD (McCutcheon et al., 2017). Since family history of remission indexes both
