Chunk #62 — Methods — Cross-ancestry lookup

Source

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals.

Embedded

yes

Text

For the 85 independent variants associated in EUR, we looked up the associations in non-EUR groups. If the variants were not observed in another ancestry, we substituted proxy SNPs defined as associated with PAU (P < 5 × 10−8) and in high LD with the EUR lead SNP (r2 ≥ 0.8).