Following a pre-specified analysis plan, we conducted a sample-size-weighted meta-analysis (N = 298,420) of cohort-level GWAS summary statistics. The phenotype measure was life satisfaction, positive affect, or (in some cohorts) a measure combining life satisfaction and positive affect. We confirmed previous findings9 of high pairwise genetic correlation between life satisfaction and positive affect using bivariate LD Score regression10 (ρ̂ = 0.981 (SE = 0.065); Supplementary Table 1). Details on the 59 participating cohorts, their phenotype measures, genotyping, quality-control filters, and association models are provided in Online Methods, Supplementary Note, and Supplementary Tables 2–6.
