Despite the differences in approaches, primary substance of abuse and/or genetic background, however, there is significant evidence that, compared to chance, the current results identify more of the same genes and chromosomal regions that are also identified by a number of independent datasets that compare substance dependence phenotypes to controls. These include the fits between the current nontemplate analyses of data from pooled African- and European-American samples and previously-reported pooled results from Asian methamphetamine dependence samples as well as individual genotyping results that compare dependent vs nondependent smokers. Analyses of cocaine dependence vs control data that has become available on dbGAP after our analyses were completed provide support for 162 of the clusters of nominally-positive result from the European-American samples reported herein by clusters of at least 4 SNPs that display p<0.05 nominal significance in this dbGAP data (Monte Carlo p<0.0001) (Drgon et al, in preparation). Data for African-American samples provides support for 147 of the clustered, nominally significant observations from our current report (Monte Carlo p<0.0001) (Drgon et al, in preparation).
