We apply our novel approach to 17 complex diseases and traits with an average sample size of 73,599. We first analyze non-cell-type-specific annotations and identify heritability enrichment in many of these functional annotations, including a large enrichment in conserved regions across many traits and a very large immunological disease-specific enrichment in FANTOM5 enhancers. We then analyze cell-type-specific annotations and identify many cell-type-specific heritability enrichments, including enrichment of central nervous system (CNS) cell types in body mass index, age at menarche, educational attainment, and smoking behavior.
