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Chunk #16 — Discussion

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Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls.
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In closing, the present findings are important in demonstrating that both early childhood experiences and OXTR SNPs can profitably be considered in understanding the relation between maternal depression and symptomatology in offspring. Future research assessing oxytocin biology should examine more explicitly, and in larger samples, quality of maternal care and levels of adversity associated with having a depressed mother. The results of this study underscore the promise of continuing to elucidate the links among maternal depression, oxytocin biology, and children's internalizing symptoms.