lower in African individuals. We next evaluated the trans-ancestry PRS in four independent self-reported Black cohorts—REGARDS [28], GenHAT [29], HyperGEN [30], and WPC [31]—collected by the University of Alabama at Birmingham (UAB). In all four UAB cohorts, T2D cases were defined with T2D ICD codes, a single measurement of glucose (fasting glucose ≥126 mg/dL [7 mmol/L] or random glucose ≥ 200 mg/dL [11.1 mmol/L]) or use of any glucose-lowering medications. Lastly, since the number of Asian participants in eMERGE was low, precluding the evaluation of the PRS in the Asian population, we sought to assess the trans-ancestry PRS in the Taiwan Biobank (TWB), a community-based prospective cohort study of the Taiwanese population, aged 30 to 70 years old at recruitment [20, 21]. TWB participants were interviewed using a structured questionnaire at one of the recruitment centers, which included questions on basic demographic information, lifestyle, environmental exposures, reproductive history, medical history, and family history. Participants with self-reported T2D history were defined as cases in the PRS analysis. After removing 1,776 REGARDS samples that overlapped with the MEDIA study, there was no remaining overlap between the discovery GWAS samples and participants in the evaluation cohorts. Figure 1 summarizes the construction and evaluation
