Data on CUD prevalence including uncertainty intervals by 5-year age bands were retrieved from the GBD study for the years 2010 to 2019 [42]. In the GBD study, CUD is defined by ICD-10 (F12.2) or DSM-IV (304.30) criteria for cannabis dependence and prevalence estimates are based on school and adult survey data. In brief, cannabis use prevalence estimates were first converted into regular use estimates and then into CUD estimates. The first conversion ratio (from any use to regular use) was determined using a meta-analytical approach, resulting in a factor of 2·9 (i.e., there is one regular user for 3 any user). The second conversion ratio (from regular use to CUD) was determined using a Bayesian meta-regression, which accounted for risk differences between youth and adults. For more details on the estimation of CUD, see supplement of [43]).
