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Chunk #16 — DISCUSSION

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Identification of ten loci associated with height highlights new biological pathways in human growth.
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We note that the accompanying manuscript by Weedon et al.18 identifies association with height for several of the loci reported in our study (ZBTB38, HMGA2, GDF5-UQCC, HHIP, SH3GL3-ADAMTSL3, CDK6), and reports, as we do, a suggestive association for a SNP at the FUBP3 locus (P = 7.5 × 10-7 in our study; P = 2.0 × 10-5 in Weedon et al.). FUBP3, a gene implicated in c-myc regulation, is therefore likely to represent an additional locus associated with height.