Chunk #35 — Developmental roles of INO80 complexes

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Chromatin remodelling during development.

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Thus, four ATP-dependent chromatin remodellers — CHD1, NURD complexes, the TIP60-p400 complex and the esBAF complex — seem to have non-redundant roles in pluripotency (Fig. 3), raising the question of whether each has a programmatic, specialized, non-overlapping role in maintaining the ‘landscape’ of pluripotent chromatin.