Chunk #59 — Data availability

Source

Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements.

Embedded

yes

Text

Data are available at: IMPACT Github repository: https://github.com/immunogenomics/IMPACT; IMPACT 707 annotations: https://github.com/immunogenomics/IMPACT/tree/master/IMPACT707. Data were obtained from the following resources: HOMER: http://homer.ucsd.edu/homer/motif/; S-LDSC: https://github.com/bulik/ldsc; 1000 Genomes: http://www.internationalgenome.org/; cell-type-specifically expressed gene set annotations and LD scores: https://data.broadinstitute.org/alkesgroup/LDSCORE/LDSC_SEG_ldscores/; cell-type-specific histone modification ChIP–seq datasets: https://data.broadinstitute.org/alkesgroup/LDSCORE/; Plink: https://www.cog-genomics.org/plink2; Riken website: http://jenger.riken.jp/en/; Price Lab GWAS summary statistics: https://data.broadinstitute.org/alkesgroup/sumstats_formatted/; Neale Lab GWAS summary statistics: http://www.nealelab.is/uk-biobank; GWAS catalog: https://www.ebi.ac.uk/gwas/; Deep Learning: https://data.broadinstitute.org/alkesgroup/LDSCORE/DeepLearning/.