The pharmacotherapy interventions used in this research appear to be safe and well tolerated. Only 4 individuals out of 1504 withdrew from the study for medication-related reasons (see above). There were more adverse events, however, among individuals in the combination pharmacotherapy versus the monotherapy or placebo conditions (see Table 4). Combination therapy did not appear to increase serious adverse events or study withdrawal in comparison to monotherapy. These findings agree with prior research that supported the safety and patient acceptance of combination NRT (e.g., 15, 25, 32, 47, 48).
