Parameter estimates for PRS in independent and conditional models.Parameter estimates (with 95% confidence intervals), from linear mixed models for alcohol use disorder (AUD) criteria regressed on polygenic risk scores (PRS) for drinks per week (GSCAN DPW), problem alcohol use (PROB ALC), and risky behaviors (RISK PC) in COGA and FT12. Independent = model with only corresponding PRS. Conditional = model with all PRS included. Adjusted for age, sex, first 10 ancestral principal components, genotyping array, and data collection site (only COGA for the latter two). All tests were two-sided.
