Significant increases of mI/Cr and mI/Cho ratios in the sarcosine group between two spectroscopies, and in comparison with the placebo group, might indicate unfavourable changes. However, some researchers report greater mI concentrations to be associated with treatment [41,70]. Thus, administration of sarcosine may secondarily activate glial cells, mostly astrocytes, because glycine transporters and other glutamatergic system transporters are abundant in their cell membranes [71].
