distant in their genomic coordinates but are inferred to be spatially close to each other in the nucleus. Both the “arc” and “heatmap” modes only display interactions that are contained within the current browsing range while omitting interactions beyond the range. To visualize the complete set of interactions, investigators can invoke the “Circlet View” (Supplementary Fig. 2). In the Circlet View, the chromosomal axis curls to form a circle and interactions are displayed as arcs inside the circle. Investigators can choose to display one single chromosome or to include interacting chromosomes to achieve a whole-genome perspective of the interactions. Gene Set View and genomic juxtaposition can be combined with the long-range interaction function to focus on the interaction events within a subregion of the genome (Figure 1). An investigator’s own long-range interaction data can be displayed on the Browser via the custom track or Data Hub function.
