stringent specificity [45, 46]. Genes associated with the stages of cortical development (pSI < 0.01) were used as the prior gene sets for the enrichment analysis. As the Combined-PC1 was derived from cortical thickness, we only focused on the gene sets related to the developmental stages of the cortex. For both enrichment analyses of GO and developmental stages, gene sets with sizes ranging from 10 to 200 genes after the intersection with the input genes list were included in the analysis.