Chunk #84 — METHODS — Statistical analysis — Gene-wise and pathway analysis

Source

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.

Embedded

yes

Text

We performed a genome-wide gene-based association analysis using the Multi-Marker Analysis of GenoMic Annotation (MAGMA) tool, as implemented in FUMA version 1.3.6a48. Using this we mapped SNPs from the depression GWAS meta-analysis to 17,840 protein coding genes, and performed Bonferroni correction for the total number of protein-coding genes (P<2.8 x 10−6, Supplementary Table S7D).