Imputation of SNPs was conducted proximal to any SNPs with genome-wide significance from the trio, case-control or trio-case-control samples. This was completed using the 1000 Genomes Project via IMPUTE2,55 and haplotypes from the 1,092 individuals in a 1000 Genomes Data Release56 as a reference dataset. Post-imputation QC and allelic dosage analysis were conducted in PLINK (see Supplementary materials).
