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Chunk #15 — Results — HDL-Cholesterol

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Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III.
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The results for HDL cholesterol are summarized in Table 3. SNPs at CETP and LPL were strongly associated with HDL cholesterol in all three ethnic groups. Each increase in minor C allele copy number in CETP polymorphism rs1800775 resulted in a 0.05 standard deviation (SD) unit decrease in HDL cholesterol across all ethnicities (P=5.0 × 10−20). LPL rs328 was associated an increase of 0.04 SD unit in HDL cholesterol per allele (P = 5 × 10−8).