Chunk #12 — Methods — Genetic correlations with other substance use disorders, psychiatric disorders, and other relevant phenotypes

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Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.

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We also estimated genetic correlations between the AFR DSM-NicDep GWAS and eight traits for which GWAS data were available from a reasonably large AFR sample. With a total sample size <5,000, it was not feasible to estimate meaningful genetic correlations using LDSC for the DSM-NicDep EAS samples.