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Chunk #164 — ONLINE METHODS — Effect of covariates on networks

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Gene expression elucidates functional impact of polygenic risk for schizophrenia.
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We examine the correlation of clinical/technical covariates, including: Institution, Gender, Age of death, PMI, RIN, Library batch and Ancestry with the Module Eigengene (ME) values from the control and SCZ networks. There was no significant association at FDR < 20% (range of Pearson’s r: −0.16 to 0.21). At nominal P value < 0.05 we found an association of M0c, M16c, M6c, M26c, M28c, M32c, M7s and M12s MEs with Institution, RIN or Library batch. We found no association of the blue (M2c) module with any covariate at P < 0.1, indicating that our differential co-regulated results are not biased from clinical or technical covariates.