across different percentage cutoffs and ancestral groups, with comparable predictive performance in the European and East Asian populations and lower prediction accuracy in the African population. Individuals in the top 2% of the PRS distribution had significantly increased T2D risk, with the OR estimates ranging from 2.55 in the African samples to 4.58 in the East Asian samples, which corresponds to the increased risk of T2D for first-degree relatives [41] and suggests a clinical value of the trans-ancestry PRS in diverse populations.
