We used four methods to identify genes associated with the three latent genomic factors: multi-marker analysis of genomic annotation (MAGMA; version 1.08; Supplementary Tables 6 and 7)30, MetaXcan31 (Supplementary Tables 8), summary-based Mendelian randomization (SMR; Supplementary Tables 9)32, and Hi-C-coupled MAGMA (H-MAGMA; Supplementary Tables 10 and 11)33. MAGMA tissue expression analyses are reported in the Supplementary Text and Supplementary Tables 12 and 13.
