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Chunk #19 — METHODS — REGRESSION ANALYSIS

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A comparison of approaches to account for uncertainty in analysis of imputed genotypes.
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First we give the models used for ordinary least squares (OLS) regression. Then, we explain the use of mixture models for regression. For each method, we consider both additive (1-parameter of 1-degree-of-freedom “1 df”) and non-additive (2-parameter, 2 df) regression models for analysis. In what follows, let yi denote the quantitative trait value for individual i at a SNP.