P2X receptors (P2XRs) are a family of 7 fast-acting subreceptors P2X1 to P2X7. These nonselective cation-gated channels receptors exhibit high Ca2+ permeability upon activation by extracellular ATP.134,135. P2X receptors are widely distributed on non-neuronal and neuronal cells and participate in numerous physiological as well as pathophysiological processes.15 Several studies have suggested the change in P2XRs expression under neuroinflammatory, nerve transmission, and pain sensation conditions.136 Activation of some P2XRs has been associated with various pathological disorders of CNS including neuroinflammation and neurodegeneration.36
