Among our next endeavors are genome‐wide scans of measures of oscillation‐based communication between distant brain areas (Fries, 2005; Stam, 2014) and oscillation dynamics (Linkenkaer‐Hansen et al., 2001). The importance of neural communication for behavior and behavioral disorders is well documented (Paus et al., 2008; Uhlhaas & Singer, 2010). EEG is widely used for establishing functional connectivity and yields a wealth of information on the synchrony between distant brain areas (Lobier et al., 2014; Nolte et al., 2004; Stam & van Dijk, 2002; Stam et al., 2007). The brain is a highly organized, nonrandom network that balances substantial wiring costs with enhanced communication capacities (Bullmore & Sporns, 2009, 2012; Stam, 2014). This optimization is obtained by a modular community structure with an uneven importance distribution across the nodes (van den Heuvel & Sporns, 2013). Areas of high importance (“hubs,” or highly central nodes) are particularly vulnerable to impairments causing large dysfunctions (Heuvel et al., 2013; Stam et al., 2009). The goal of ENIGMA‐EEG is to elucidate how genetic variants influence communication between brain areas and the connectivity patterns of the network, matching those variants to neurological and psychiatric disorders.
