Chunk #27 — Results — Gene–environment correlation and interaction

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Interaction between polygenic risk for cigarette use and environmental exposures in the Detroit Neighborhood Health Study.

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We found evidence of rGE between the GRS and neighborhood physical disorder (r2=0.14, P<0.01), but no significant correlation was observed between the GRS and neighborhood social cohesion or number of traumatic events. Due to the significant rGE observed between the GRS and neighborhood physical disorder, we did not test for GxE with this social environment.