APBB1 spans approximately 24 kb, consisting of 15 exons. The protein encoded by APBB1 is an adaptor protein localized in the nucleus, which belongs to Fe65 protein family. As a regulatory factor, APBB1 interacts with actions of amyloid precursor protein (APP). Through APBB1, the signaling pathway consisting of transient axonal glycoprotein-1 and APP (TAG1-APP) negatively modulates neurogenesis (Ma et al. 2008). Moreover, through enhanced production of the carboxyl-terminal fragment substrates of γ-secretase as well as direct stimulation of processing by γ-secretase, APBB1 stimulates γ-secrete-mediated libration of the APP intercellular domain. On the other hand, multiple splicing transcript variants of APBB1 lead to different stimulating capabilities of the proteins encoded (Wiley et al. 2007).
