negative regression coefficient; r2 value, 9%-14%) (Figure 1). One of these SNPs, rs3933331, is located about 100 kb upstream of the SLC1A1 transcription initiation site, while the 2 other eQTL SNPs, rs7858819 and rs301430, are in the 3′ end of SLC1A1. Remarkably, rs301430 has recently been associated with early-onset OCD in a collection of 71 trios both individually and as part of a haplotype,17 and the haplotypic association has been replicated subsequently.18
