The liver to body wt ratio was elevated by about 35% by ethanol in WT mice (Fig. 2E). A similar increase by ethanol was found with the KO mice, despite only a modest increase in triglycerides as compared to the WT mice. A near two-fold increase in the liver to body wt ratio was found with the ethanol-fed KI mice even though triglycerides were elevated by ethanol in these mice to a lesser extent than the WT mice. This suggests that other macromolecules besides fat contribute to elevated liver/body wt ratio in the ethanol-fed KO and KI mice.
