of connectivity in the default network, and proposed that lateral prefrontal regions may actively suppress activation of midline structures to augment performance. Similarly, a greater inverse correlation between activity in the default network and task-related activation was positively associated with intra-individual consistency in behavioral performance (Clare Kelly et al., 2008). In other words, the strength of the correlation may represent an index of neural regulation between default and task-active “modes” (Clare Kelly et al., 2008). Together, current findings suggest that adolescents with dense FH may be less successful in moderating the default network in response to cognitive load. This difference could have potential consequences for downstream cognitive functioning, or serve as an additional endophenotype to help identify youth at greater risk of developing CNS disinhibitory related behaviors.
