processing. We also predicted differential amygdalar response to the masked affective stimuli, given the CB1 receptors located within the amygdala-prefrontal circuit (Laviolette and Grace, 2006), which have been shown to modulate emotional associative learning. Given previous fMRI findings of altered cingulate activation in chronic, heavy marijuana smokers during tasks requiring inhibitory function, we hypothesized that relative to the non-marijuana smoking control subjects, the chronic marijuana smokers would demonstrate reduced cingulate activity during the masked affective tasks and altered amygdalar activity, which may be correlated with measures of marijuana use.
