significantly associated regions overlapped with previously reported genome-wide significant regions from at least one individual disorder, while 35 loci (25.7%) represented novel genome-wide significant associations. Simulation analyses confirmed that the number of pleiotropic loci we identified exceeds chance expectation given the sample size and genetic correlations among the eight disorders (p < 9.9×10−3; Data S1.5; for further details, see Online Methods).
