pattern is the concentration of TFs in the TSS-associated state. The enhancers contain a different set of TFs. For example, in K562, the E state is enriched for binding by the proteins encoded by the EP300, FOS, FOSL1, GATA2, HDAC8, JUNB, JUND, NFE2, SMARCA4, SMARCB1, SIRT6, and TAL1 genes. We tested a subset of these predicted enhancers in both Mouse and Fish transgenic models (examples in Figure 6), with over half of the elements showing activity, often in the corresponding tissue type.
