[Carlson, et al. 2004]. Under this definition and using the 1000 Genomes Pilot 1 CEU as the European ancestry reference sample [Durbin, et al. 2010], the single bin tagged by rs16969968 and rs1051730 includes 52 known variants. This bin, which we will call bin A, groups together and unifies the most significant meta-analysis findings as well as individual dataset reports of SNPs associated with nicotine dependence, heavy smoking, lung cancer, and other smoking related diseases in European ancestry datasets.
