Main effects for family history group, age (13 – 14, 15 – 16, 17 – 18 years), and sex were included in the initial model. Subsequent follow-up analyses explored family history × age and family history × sex interactions. False discovery rate (FDR) correction for multiple comparisons35 was applied to the group ICA analyses (corrected p = .05). For intranetwork connectivity, FDR was applied for each component. For internetwork connectivity, FDR was applied to the group comparison of the FNC correlations. Associations between significant connectivity findings and neuropsychological performance on the Trails A, Trails B, Digit Span, and Visuospatial Sequencing tests were explored. Finally, for significant differences between family history groups, follow-up analyes were computed to determine whether these results were associated with number of first- and second-degree family members with AUD and/or mood disorders.
