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Chunk #32 — METHODS — Data Acquisition and Analysis — Standardized Low Resolution Tomography Analysis (sLORETA)

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Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task.
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sLORETA values for these time-samples were computed for each condition and subject separately using ASCII values, electrode coordinates, and the transformation matrix. To answer the “Where” question, obtained sLORETA values were subjected to paired and independent tests to find out the differences between conditions and groups, respectively. For each comparison, one single test (Log of ratio of averages) was calculated for all five time-samples for each analysis with 5000 random permutations (i.e., bootstrapping) and levels of significance were corrected for multiple comparisons and false positives. The resultant values were then plotted and evaluated for the level of significances. The maximum differences between conditions and groups at respective MNI coordinates and Brodmann areas (BA) are reported.