Several genes of moderate effect have been detected by GWAS, including variants near CAV1 and CAV2 [9] and TMCO1 and CDKN2B [11]. We assessed evidence for a list of well replicated published genes in our GWAS (Table 4) and found the genes SRBD1, CDKN2B, and TMCO1 had the most convincing evidence of association in our data. Interestingly, the best SNP within SRBD1 is rs11884064 (p=6.7×10−5), though nearby rs1657855 is marginally more significant (p=2.69×10−5) and located upstream of SRBD1 and nearer the SIX3 and SIX2 genes which play roles in eye development.
