BrAC was uniformly zero before imaging on both session days in all subjects. BrAC measured immediately after subjects left the scanner room during the IV alcohol infusion session was 0.054 for AA genotypes (SD= 0.005) and 0.052 (SD= 0.007) for AG genotypes, a difference that was not significant. During placebo infusion, subjects rated being “high” and “intoxicated” as uniformly low (means < 3) on the 0 – 100 scale of the SHAS. As tested in a Genotype(2) × Time(4) linear mixed-effects model (using the four time points after the uniform ‘0’ baseline), there was a significant Genotype effect (F= 5.141,34, p< 0.05), with AA subjects feeling less high throughout (Figure 1, top). Employing the presence of an alcohol use disorder as a covariate to address the possible effects of tolerance did not change the significance of the genotype differences for perceived “high.” While there was a significant main effect of Time (F= 9.541,28, p< 0.05) that reflected progressive increases from the first time point after baseline, the Genotype × Time interaction was not significant. There was a significant Time main
