bias estimates of genetic correlation when studies utilize super-normal controls that are screened both for the disorder of interest and related disorders (Kendler, Chatzinakos, & Bacanu, 2020). It is worth noting that the upward bias was found to be most pronounced for traits with a population prevalence higher than what is commonly observed for the majority of psychiatric traits (e.g., > 15%). Simulations then indicate both that estimated genetic correlations across psychiatric traits are likely upwardly biased, but are highly unlikely to be entirely artifactual.
